20 noiembrie 2021
Sâm, 20.11
21:30
Philadelphia Union
Philadelphia Union
1
New York Red Bulls
New York Red Bulls
0
Dum, 21.11
00:00
Sporting Kansas City
Sporting Kansas City
3
Vancouver Whitecaps
Vancouver Whitecaps
1
21 noiembrie 2021
Dum, 21.11
22:00
New York City FC
New York City FC
2
Atlanta United
Atlanta United
0
Lun, 22.11
00:30
Portland Timbers
Portland Timbers
3
Minnesota United
Minnesota United
1
24 noiembrie 2021
Mie, 24.11
03:00
Nashville SC
Nashville SC
3
Orlando City
Orlando City
1
Mie, 24.11
05:30
Seattle Sounders FC
Seattle Sounders FC
5
Real Salt Lake
Real Salt Lake
6
Etapa următoare